Abstract
"The nervous system of the gut is affected by some of the same abnormalities as the brain in individuals with Parkinson's. The idea has therefore been put forward that the gut might provide a 'window to the brain' through which we can see the changes of Parkinson's whilst the disease is in it's earliest stages. This might have implications, not only for diagnosis, but also for monitoring of early disease.
This new study reports the likelihood of picking up these gut abnormalities in individuals with Parkinson's and shows that the likelihood is site dependent. Biopsy of the gut is not a standard investigation in people with Parkinson's currently and is unlikely to be in the near future. However, this study is relevant because clinical trials of early disease may consider using gut biospies, and this study shows that biospy of the rectum alone is unlikely to be adequate."
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