Parkinsonism Relat Disord. 2011 Nov 25. [Epub ahead of print]
Ton TG, Jain S, Biggs ML, Thacker EL, Strotmeyer ES, Boudreau R, Newman AB, Longstreth WT Jr, Checkoway H.
BACKGROUND:
Studies
demonstrate existence of inflammation in prevalent Parkinson's disease
(PD). We assessed associations of baseline levels of inflammatory
markers with prevalent PD at baseline (1989) and incident PD identified
over 13 years of follow-up of the Cardiovascular Health Study.
METHODS:
Blood
samples at baseline were measured for fibrinogen, interleukin-6, tumor
necrosis factor-α, C-reactive protein, albumin, and white blood cells.
The analysis included 60 prevalent and 154 incident PD cases.
RESULTS:
Risk
of prevalent PD was significantly higher per doubling of IL-6 among
women (odds ratio [OR]=1.5, 95% confidence interval [CI]: 1.0, 2.4) and
WBC among men (OR: 2.4, 95% CI: 1.2, 4.9) in multivariate models. Risk
of incident PD was not associated with higher levels of any biomarker
after adjusting for age, smoking, African American race, and history of
diabetes. Inverse associations with incident PD were observed per
doubling of C-reactive protein (OR=0.9; 95% CI: 0.8, 1.0) and of
fibrinogen among women (OR=0.4; 95% CI: 0.2, 0.8).
CONCLUSIONS:
Although
inflammation exists in PD, it may not represent an etiologic factor.
Our findings suggest the need for larger studies that measure
inflammatory markers before PD onset.
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