Neurodegener Dis. 2011 Dec 23. [Epub ahead of print]
Li X, Sundquist J, Sundquist K.
Abstract
Objectives:
To investigate associations between autoimmune disorders and Parkinson
disease (PD), and to study whether the risk is associated with
follow-up time and age. Methods: Standardized incidence ratios (SIRs)
were calculated for PD in patients with autoimmune disorders by
comparing them to subjects without autoimmune disorders. Results: Among
310,522 patients with a total of 33 conditions of autoimmune disorders,
932 patients developed subsequent PD, giving an overall SIR of 1.33 and
1.19 for PD diagnosed later than 1 year after follow-up. Six types of
autoimmune disorders showed an increased risk. These conditions
included: amyotrophic lateral sclerosis, Graves's
disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple
sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks
depended on the age at hospitalization for PD. Conclusions: A 33%
overall excess risk of PD was noted among patients with an autoimmune
disorder; the risk was increased during the first 10 years of follow-up
after hospitalization of autoimmune disorders.
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