Neurodegener Dis. 2012 Mar 6. [Epub ahead of print]
Monastero R, Di Fiore P, Ventimiglia GD, Ventimiglia CC, Battaglini I, Camarda R, Camarda C.
Source
Laboratory
of Epidemiology and Psychology of Aging and Dementia (LEPAD),
Department of Experimental Biomedicine and Clinical Neuroscience
(BioNeC), University of Palermo, Palermo, Italy.
Background/Aims:
The frequency of mild cognitive impairment (MCI) in Parkinson's disease
(PD) ranges from 19 to 40%, and this is probably due to methodological
differences between the studies. The aim of this study was to evaluate
the frequency and profile of MCI in a large sample of nondemented PD
subjects and neurologically healthy subjects (NHS). Methods: A total of
872 subjects (582 controls and 290 PD) were included. The association
between MCI and PD was tested, using logistic regression models; odds
ratios (OR) with 95% confidence intervals (CI) were calculated.
Results: Fifty-three percent of PD subjects and 45% NHS met the
criteria for MCI (p = 0.001). The PD subjects showed a higher frequency
of nonamnestic MCI (naMCI), compared to NHS (23.8 vs. 14.4%, p ≤
0.0001). In comparison to NHS, PD was associated with a univariate OR
of 1.9 (95% CI = 1.3-2.8) for naMCI, and this association was
marginally significant after multiple comparisons (multivariate OR =
1.5, 95% CI = 0.96-2.3, p = 0.077). Conclusion: The association between
PD and the impairment of nonmemory domains is probably due to
frontal-subcortical involvement, which characterizes the disease.
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