Nizatidine ameliorates gastroparesis in Parkinson's disease: A pilot study

Mov Disord. 2013 Dec 27. doi: 10.1002/mds.25777. [Epub ahead of print]

Doi H, Sakakibara R, Sato M, Hirai S, Masaka T, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Takahashi O, Ogata T.

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Pharmaceutical Unit, Sakura Medical Center, Toho University, Sakura, Japan.

Abstract

BACKGROUND:

The objective of this work was to perform an open trial of the effects of nizatidine (NZT), a selective histamine H2-receptor antagonist and a cholinomimetic, on gastroparesis in Parkinson's disease (PD) patients, using objective parameters given by a gastric emptying study using a 13 C-sodium acetate expiration breath test.

METHODS:

Twenty patients with PD were enrolled in the study. There were 13 men and 7 women; aged 68.0 ± 7.72 years; disease duration 5.50 ± 3.62 years. All patients underwent the breath test and a gastrointestinal questionnaire before and after 3 months of administration of NZT at 300 mg/day. Statistical analysis was performed by Student t test.

RESULTS:

NZT was well tolerated by all patients and none had abdominal pain or other adverse effects. NZT significantly shortened Tmax (13 C) (the peak time of the 13 C-dose-excess curve) (P < 0.05).

CONCLUSIONS:

Although this is a pilot study, we found a significant shortening of gastric emptying time after administration of NZT in PD patients.