The link between Parkinson's disease and breast and prostate cancers: A meta-analysis

That settles that then...

Int J Neurosci. 2014 Nov 11:1-26. [Epub ahead of print]

Wang T

Purpose: Clinical observations have shown an increased morbidity for breast cancer or prostate cancer in patients with Parkinson's disease, however, other reports have noted contradictory results. This pooled analysis was utilized to test whether Parkinson's disease is associated with the risk of breast or prostate cancer. Methods: We searched PubMed, Embase and Cochrane library and conducted a meta-analysis to clarify the correlation of Parkinson's disease with breast and/or prostate cancer risk. We identified 16 eligible articles from which odds ratios with 95% confident intervals were assessed as main measures in the pooled estimation. Subgroup analyses and cumulative meta-analysis were also performed. Results: Our results showed no Parkinson's disease risk associated with breast or prostate cancer in the overall population, which was supported by the results of cumulative meta-analyses. The subgroup analyses suggested no significant risk of breast or prostate cancer in patients with Parkinson's disease within relevant subsets, i.e. gender, ethnicity, Parkinson's disease diagnosis time, or study design. No evidence of publication bias was observed across the involved studies. Conclusions: This meta-analysis indicates a lack of association between Parkinson's disease and risk of breast or prostate cancer.