We see this occasionally in the clinic... and there are lots of lines of evidence to suggest an association...
Parkinsonism Relat Disord. 2015 Oct 9. pii: S1353-8020(15)00421-6. doi: 10.1016/j.parkreldis.2015.09.032. [Epub ahead of print]
Thenganatt MA, Jankovic J.
Abstract
Essential tremor (ET) and Parkinson's disease (PD) are the two most common tremor disorders encountered in a movement disorders clinic. Although distinct clinical-pathological entities, both disorders may share overlapping features in addition to rest and postural tremor, such as bradykinesia, rigidity, gait and balance impairment and some non-motor signs. A subset of patients may have a combination of long-standing ET with subsequent PD (ET-PD). There are several lines of evidence from clinical, epidemiologic, imaging, genetic and pathologic studies supporting a link between ET and PD, greater than by chance alone. In this review we will discuss the latest data supporting a relationship between ET and PD and the implications for possible pathogenic link and treatment.
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