Nice early christmas present to have this published today... I anticipate this approach will take us forward in understanding the causal nature of Parkinson's... particularly when it comes to the associations with some of the stranger environmental exposures for PD...
Mov Disord. 2015 Dec 23. doi: 10.1002/mds.26492. [Epub ahead of print]
Noyce AJ, Nalls MA.
Parkinson's disease has multiple determinants and is associated with a wide range of exposures that appear to modify risk in traditional observational studies, including numerous lifestyle and environmental factors. Across other fields of medicine, Mendelian randomization has emerged as a powerful method to examine whether associations between exposures and disease outcomes are causal. Here we discuss the concept of Mendelian randomization, its potential relevance to Parkinson's disease, and suggest avenues through which the method could be employed to further understanding of the causal basis of Parkinson's disease.
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