Results from meta-analysis confirming age-related increase in PD incidence but also supporting the notion of a 'levelling-off' after the age of 80 years. Gender differences also observed consistent with what we know...
Neuroepidemiology. 2016 Apr 23;46(4):292-300. [Epub ahead of print]
Hirsch L, Jette N, Frolkis A, Steeves T, Pringsheim T.
BACKGROUND:
Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history.
OBJECTIVE:
This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender.
METHODS:
We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups.
RESULTS:
Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05).
CONCLUSION:
PD incidence generally increases with age, although it may stabilize in those who are 80+.
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