This marks another NY resolution to speak and flag more about the research that I/we think is interesting or important in the early identification or prediction of PD. In addition, we like to mention good quality clinical and genetic studies that tell us more about PD in general (not just prediction and early identification).
First off, the latest from the CAMPAIGN study. CAMPAIGN is one of the most rigorous and thorough long term studies of PD. The team have managed to follow up the people that they recruited with PD for a long, long time in order to help us learn more about the features that emerge over time.
In the present study, they show that eventually motor complications may be inevitable and that current drugs become less effective/predictable over time. Importantly they provide further support for the notion that levodopa replacement itself is not a cause of motor fluctuations and that thoughts about saving levodopa for the future (i.e. not starting after diagnosis) are probably outdated ideas.
Ultimately, whilst the available treatment options are good for most patients, the results here support our ongoing desire to find drugs that delay progression rather than just manage the symptoms...
The link to the study is here and it is open access (👌). The abstract is copied below.
https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27882
Alastair Noyce
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