Addenbrooke's Cognitive Examination-Revised for mild cognitive impairment in Parkinson's disease

Mov Disord. 2012 Jun 25. doi: 10.1002/mds.25084. [Epub ahead of print]

McColgan P, Evans JR, Breen DP, Mason SL, Barker RA, Williams-Gray CH.

Source

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. 

Abstract

INTRODUCTION:

Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed.

METHODS:

We investigated the utility of the Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment (MCI) in PD in an incident population-representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219).

RESULTS:

Twenty-two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory-Revised and Parkinson's Disease Questionnaire 39.

CONCLUSION:

This instrument is a useful screening tool for PD-MCI, and poor performance is significantly related to impaired behavior and quality of life.