Mov Disord. 2012 Jun 12. doi: 10.1002/mds.25070. [Epub ahead of print]
Lessig S, Nie D, Xu R, Corey-Bloom J.
Source
Department
of Neurosciences, University of California San Diego, San Diego,
California, USA; VA Medical Center San Diego, San Diego, California,
USA. slessig@ucsd.edu.
Abstract
Two
hundred and twenty-one subjects with Parkinson's disease (PD) were
examined using the Mini-Mental Status Examination (MMSE) and Montreal
Cognitive Assessment (MoCA), with a subset of these (n = 98) examined
on repeat testing up to 3 years. The MoCA was more sensitive in
identifying cognitive deficit, specifically in the domains of
visuospatial abilities, language, and memory. In longitudinal study,
the MMSE changed significantly over time, particularly in patients with
disease duration of >10 years. The MoCA, however, did not change
significantly, even when subjects were stratified by age, MMSE score,
and disease duration. This suggests that the MoCA may be more sensitive
for detecting early cognitive change in PD, but that the MMSE, and not
the MoCA, may be better for tracking cognitive decline.
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