Acta Neurol Scand. 2017 Jun 26. doi: 10.1111/ane.12793. [Epub ahead of print]
Friday 30 June 2017
Association between Parkinson's disease and diabetes: Data from NEDICES study.
There is increasing evidence of a link between diabetes and Parkinson's... I had always assumed that any association between vascular risk factors and parkinsonism was driven by vascular disease mimicking PD or mixed pathology, rather than being associated with PD per se. But it is time to consider the alternative now that increasing data are available and drugs used to treat diabetes are being trialled for Parkinson's...
Despite growing evidence showing an association between Parkinson's disease (PD) and diabetes, epidemiological studies have shown conflicting results.
To evaluate the association between PD and diabetes and the impact of diabetes duration in this association in an elderly (≥65 years) Spanish population.
Data for this cross-sectional population-based analysis were obtained from NEDICES study. Subjects were identified from census list. Diagnosis of PD was confirmed by neurological examination. Diabetes was defined by self-report, being on antidiabetic medication or diagnosis on medical records. Logistic regression analysis adjusted by potential confounders was performed to estimate the association between both conditions and also after dividing patients into short-duration (<10 years) and long-duration (≥10 years) diabetes.
A total of 4998 subjects were included (79 PD and 4919 controls). Univariate analysis did not show any association between prevalence of PD and diabetes (OR 1.89, 95% CI 0.90-3.98, P=.09), although subgroup analysis showed a positive association in those with long-duration diabetes (3.27, 95% CI 1.21-8.85, P=.02).
Diabetes duration might be an important factor in the association between PD and diabetes, and the risk might be limited to those with longer disease duration.
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