Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.
Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, Kordower JH.
Mov Disord. 2011 Jul 15. doi: 10.1002/mds.23838. [Epub ahead of print]
" Alpha-synuclein is a protein that accumulates in the brain cells of people with Parkinson's. It is considered the key finding for confirming a diagnosis of Parkinson's at post-mortem. This study shows that it may be possible to identify this protein in other tissues, potentially very early in the disease. It may prove a useful marker for disease progression or monitoring response to treatment. However, further work is needed in the gut and other tissues."
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