Front Neurol. 2012;3:82. Epub 2012 May 17.
Gagnon JF, Bertrand JA, Génier Marchand D.
Source
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal Montréal, QC, Canada.
Abstract
Rapid
eye movement (REM) sleep behavior disorder (RBD) is a parasomnia
characterized by excessive muscle activity and undesirable motor events
during REM sleep. RBD occurs in approximately 0.5% of the general
population, with a higher prevalence in older men. RBD is a frequent
feature of dementia with Lewy bodies (DLB), but is only rarely reported
in Alzheimer's disease. RBD is also a risk factor for
α-synuclein-related diseases, such as DLB, Parkinson's disease (PD),
and multiple system atrophy. Therefore, RBD has major implications for
the diagnosis and treatment of neurodegenerative disorders and for
understanding specific neurodegeneration patterns. Several markers of
neurodegeneration have been identified in RBD, including cognitive
impairments such as deficits in attention, executive functions,
learning capacities, and visuospatial abilities. Approximately 50% of
RBD patients present mild cognitive impairment. Moreover, RBD is also
associated with cognitive decline in PD.
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