Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):343-52. Epub 2012 Aug 22.
Armstrong MJ, Naglie G, Duff-Canning S, Meaney C, Gill D, Eslinger PJ, Zadikoff C, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Fox S, Tang-Wai DF, Marras C.
Source
Toronto Western Hospital Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Ont., Canada.
Abstract
BACKGROUND/AIMS:
The role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood.
METHODS:
The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models.
RESULTS:
Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not.
CONCLUSION:
The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies.
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