Acta Neurol Scand. 2012 Sep 23. doi: 10.1111/ane.12012. [Epub ahead of print]
Constantinescu R, Andreasson U, Holmberg B, Zetterberg H.
Source
Department of Neurology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Abstract
BACKGROUND:
Low levels of serum urate are associated with a higher risk of Parkinson's disease (PD). Higher serum and cerebrospinal fluid (CSF) urate levels are associated with slower rates of clinical decline in PD and in multiple system atrophy (MSA).
AIMS:
To compare CSF and blood urate levels in healthy controls, patients with synucleinopathies and with tauopathies.
METHODS:
We investigated urate levels in serum and CSF from 18 healthy controls, 19 patients with synucleinopathies (six patients with PD and 13 with MSA), and 24 patients with tauopathies (18 with progressive supranuclear palsy and six with corticobasal degeneration). None of the patients were treated with dopaminergic medications.
RESULTS:
No significant differences were seen when comparing serum and CSF urate levels from controls across the parkinsonian diagnostic groups. However, in men, serum urate levels were significantly lower in the synucleinopathy group compared with the tauopathy group (P = 0.046), although with a broad overlap.
CONCLUSION:
Our study suggests that urate levels might provide new insights into the potential pathophysiological mechanisms underlying Parkinsonism and thereby contribute to the future management of these disorders.
I think this is interesting. There have been a number of studies looking at the levels of serum urate prior to a diagnosis of the Parkinson's. As far as I know this is the first to look at the difference in CSF urate across these groups. Some believe that urate may be protecting against oxidative stress and that if urate is low then unchecked oxidative stress may contribute to the causation of Parkinson's.
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