I have not seen much on migraine and PD in the past... I wonder if the authors adjusted for smoking, coffee and alcohol, which are negatively associated with PD and can trigger headaches in those with migraine...
Cephalalgia. 2016 Feb 6. pii: 0333102416630577. [Epub ahead of print]
Wang HI, Ho YC, Huang YP, Pan SL.
BACKGROUND:
The association between migraine and Parkinson's disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD.
METHODS:
A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41,019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD.
RESULTS:
During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25-2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group (p = 0.0041).
CONCLUSIONS:
This study showed an increased risk of developing PD in patients with migraine.
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