There's definitely mileage in continuing to explore gut for biomarkers... defining the appearances in healthy people is key since positive staining for alpha-synuclein is common in controls... but the conformation of this may dictate what is and what is not pathological...
Neurogastroenterol Motil. 2016 Feb 23. doi: 10.1111/nmo.12797. [Epub ahead of print]
Corbillé AG, Clairembault T, Coron E, Leclair-Visonneau L, Preterre C, Neunlist M, Derkinderen P.
BACKGROUND:
The intraneuronal inclusions called Lewy bodies and neurites, which represent the characteristic pathological changes in Parkinson's disease, are found in the enteric neurons in the great majority of parkinsonian patients. This observation led to a substantial amount of research over the last few years in order to develop a minimally invasive diagnostic procedure in living patients based on gastrointestinal (GI) biopsies.
PURPOSE:
In this review, we will begin by discussing the studies that focused on the detection of Lewy bodies and neurites in GI biopsies, then broaden the discussion to the pathological changes that also occur in the enteric glial cells and intestinal epithelial cells. We conclude by proposing that a GI biopsy could represent a unique window to assess the whole pathological process of the brain in Parkinson's disease.
© 2016 John Wiley & Sons Ltd.
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