Parkinsons Dis. 2012;2012:308097. Epub 2012 Aug 30.
Leroi I, Pantula H, McDonald K, Harbishettar V.
Source
Institute
of Brain, Behavior and Mental Health, School of Community-Based
Medicine, University of Manchester, Jean McFarlane Building, Oxford
Road, Manchester M13 9PL, UK.
Abstract
Neuropsychiatric
symptoms commonly complicate Parkinson's disease (PD), however the
presence of such symptoms in mild cognitive impairment (PD-MCI)
specifically has not yet been well described. The objective of this
study was to examine and compare the prevalence and profile of
neuropsychiatric symptoms in patients with PD-MCI (n = 48) to those
with PD and no cognitive impairment (PD-NC, n = 54) and to those with
dementia in PD (PDD, n = 25). PD-MCI and PDD were defined using
specific consensus criteria, and neuropsychiatric symptoms were
assessed with the 12-item Neuropsychiatric Inventory (NPI). Self-rated
apathy, depression, and anxiety rating scales were also administered.
Over 79% of all participants reported at least one neuropsychiatric
symptom in the past month. The proportion in each group who had total
NPI scores of ≥4 ("clinically significant") was as follows: PD-NC,
64.8%; PD-MCI, 62%; PDD 76%. Apathy was reported in almost 50% of those
with PD-MCI and PDD, and it was an important neuropsychiatric symptom
differentiating PD-MCI from PD-NC. Psychosis (hallucinations and
delusions) increased from 12.9% in PD-NC group; 16.7% in PD-MCI group;
and 48% in PDD group. Identifying neuropsychiatric symptoms in PD-MCI
may have implications for ascertaining conversion to dementia in PD.
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